Neurodegeneration as a consequence of failed mitochondrial maintenance
نویسندگان
چکیده
منابع مشابه
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متن کاملMitochondrial Dysfunction in Neurodegeneration
The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). One example of this is mitochondria...
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متن کاملTopic: Mitochondrial Dysfunction in Neurodegeneration
Neurodegenerative diseases such as Parkinson's disease (PD) are of growing public health concern in developed countries and the need for novel effective treatments continues to increase. Neurodegenerative diseases take many forms, reflecting the degeneration of different populations of neurons at different times from distinct causes, but many of them also share common features. Amongst the comm...
متن کاملNeurodegeneration in Primary Mitochondrial Disorders
A.K. Reeve et al. (eds.), Mitochondrial Dysfunction in Neurodegenerative Disorders, DOI 10.1007/978-0-85729-701-3_2, © Springer-Verlag London Limited 2012 Abstract Mitochondria are critically responsible for the generation of energy in the form of ATP through the electron transport chain (ETC). The central nervous system (CNS) performs highly energy-intensive tasks and is therefore particularly...
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ژورنال
عنوان ژورنال: Acta Neuropathologica
سال: 2011
ISSN: 0001-6322,1432-0533
DOI: 10.1007/s00401-011-0921-0